Altered Intrinsic Functional Connectivity of Anterior and Posterior Insula Regions in High-Functioning Participants With Autism Spectrum Disorder
until further notice
SourceHuman Brain Mapping, 32, 7, (2011), pp. 1013-1028
Article / Letter to editor
Display more detailsDisplay less details
SW OZ DCC CO
SW OZ DCC BO
Donders Centre for Cognitive Neuroimaging
F.C. Donders Centre for Cognitive Neuroimaging
Human Brain Mapping
SubjectAction, intention, and motor control; DI-BCB_DCC_Theme 2: Perception, Action and Control; 110 012 Social cognition of verbal communication; DCN 1: Perception and Actions NCEBP 9: Mental Health
Impaired understanding of others' sensations and emotions as well as abnormal experience of their own emotions and sensations is frequently reported in individuals with Autism Spectrum Disorder (ASD). It is hypothesized that these abnormalities are based on altered connectivity within "shared'' neural networks involved in emotional awareness of self and others. The insula is considered a central brain region in a network underlying these functions, being located at the transition of information about bodily arousal and the physiological state of the body to subjective feelings. The present study investigated the intrinsic functional connectivity properties of the insula in 14 high-functioning participants with ASD (HF-ASD) and 15 typically developing (TD) participants in the age range between 12 and 20 years by means of "resting state'' or "nontask'' functional magnetic resonance imaging. Essentially, a distinction was made between anterior and posterior regions of the insular cortex. The results show a reduced functional connectivity in the HF-ASD group, compared with the TD group, between anterior as well as posterior insula and specific brain regions involved in emotional and sensory processing. It is suggested that functional abnormalities in a network involved in emotional and interoceptive awareness might be at the basis of altered emotional experiences and impaired social abilities in ASD, and that these abnormalities are partly based on the intrinsic functional connectivity properties of such a network.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.