Mimicking the micro-environment. Construction and evaluation of complex collagen-based scaffolds for tissue engineering
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S.l. : s.n.
Radboud Universiteit Nijmegen, 19 oktober 2012
Promotores : Brock, R.E., Schalkwijk, J. Co-promotores : Daamen, W.F., Kuppevelt, A.H. van
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SubjectNCMLS 2: Immune Regulation
The ultimate goal in tissue engineering is to create biomaterials that mimic normal tissue or are able to encourage cells cells to generate new functional tissue. For these biomaterials, it is important to use highly purified components in order to moderate the tissue response and to control the regeneration process. Using type I collagen, elastin, glycosaminoglycans and a variety of growth factors as basic components, a wide variety of biomaterials can be prepared. The purpose of this thesis is to design, develop and evaluate a new molecularly defined skin construct that closely mimics normal tissue. A biologically active growth factor was made for that reason. Different biomaterials were developed and tested in laboratory animals to evaluate tissue reaction, calcification and vascularization. Following these results, a skin construct was made and analyzed in an animal model for acute wounds. First results are promising for future development.
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