The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study
SourceInternational Journal of Geriatric Psychiatry, 26, 7, (2011), pp. 702-710
Article / Letter to editor
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PI Group Memory and Emotion
Epidemiology, Biostatistics & HTA
F.C. Donders Centre for Cognitive Neuroimaging
International Journal of Geriatric Psychiatry
Subject110 012 Social cognition of verbal communication; 150 000 MR Techniques in Brain Function; DCN 1: Perception and Action; DCN 1: Perception and Actions NCEBP 9: Mental Health; DCN 2: Functional Neurogenomics; IGMD 3: Genomic disorders and inherited multi-system disorders; IGMD 3: Genomic disorders and inherited multi-system disorders DCN 2: Functional Neurogenomics; NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection
OBJECTIVE: Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life. METHODS: Multivariate logistic regression in a survey of 1396 population-dwelling people aged >/=70 years. CRDS were defined as scoring >/=16 on the CES-D. Vascular disease was categorised into four levels: none, >/=2 vascular risk factors, cardiac disease or stroke. RESULTS: Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4-1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6-0.96) when predicting CRDS. CONCLUSIONS: In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
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