Author(s):
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Broen, J.C.A.;
Coenen, M.J.H.
; Rueda, B.;
Witte, T.J.M. de
; Padyukov, L.; Klareskog, L.; Hesselstrand, R.; Wuttge, D.M.; Simeon, C.; Ortego-Centeno, N.; Gonzalez-Gay, M.A.; Pros, A.; Hunzelman, N.; Riemekasten, G.; Kreuter, A.;
Vonk, M.C.
; Scorza, R.; Beretta, L.; Airo, P.;
Riel, P.L. van
; Kimberly, R.; Martin, J.; Edberg, J.;
Radstake, T.R.D.J.
|
Subject:
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IGMD 3: Genomic disorders and inherited multi-system disorders NCEBP 1: Molecular epidemiology NCEBP 2: Evaluation of complex medical interventions N4i 4: Auto-immunity, transplantation and immunotherapy NCMLS 1: Infection and autoimmunity N4i 4: Auto-immunity, transplantation and immunotherapy ONCOL 3: Translational research NCMLS 2: Immune Regulation |
Organization:
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Rheumatology Human Genetics Tumorimmunology Haematology |
Journal title:
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The Journal of Rheumatology
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Abstract:
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OBJECTIVE: To investigate the role of the Fc(alpha)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(alpha)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(alpha)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
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