The functional polymorphism 844 A>G in FcalphaRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Abstract

OBJECTIVE: To investigate the role of the Fc(alpha)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(alpha)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(alpha)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.