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Title: The functional polymorphism 844 A>G in FcalphaRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility
Author(s): Broen, J.C.A.; Coenen, M.J.H. ; Rueda, B.; Witte, T.J.M. de ; Padyukov, L.; Klareskog, L.; Hesselstrand, R.; Wuttge, D.M.; Simeon, C.; Ortego-Centeno, N.; Gonzalez-Gay, M.A.; Pros, A.; Hunzelman, N.; Riemekasten, G.; Kreuter, A.; Vonk, M.C. ; Scorza, R.; Beretta, L.; Airo, P.; Riel, P.L. van ; Kimberly, R.; Martin, J.; Edberg, J.; Radstake, T.R.D.J.
Publication year: 2011
Source: The Journal of Rheumatology, vol. 38, iss. 3, (2011), pp. 446-449
ISSN: 0315-162X
DOI: https://doi.org/10.3899/jrheum.100427
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/98429   http://hdl.handle.net/2066/98429

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Subject: IGMD 3: Genomic disorders and inherited multi-system disorders NCEBP 1: Molecular epidemiology
NCEBP 2: Evaluation of complex medical interventions N4i 4: Auto-immunity, transplantation and immunotherapy
NCMLS 1: Infection and autoimmunity N4i 4: Auto-immunity, transplantation and immunotherapy
ONCOL 3: Translational research NCMLS 2: Immune Regulation
Organization: Rheumatology
Human Genetics
Tumorimmunology
Haematology
Journal title:
The Journal of Rheumatology
Volume: vol. 38
Issue: iss. 3
Page start: p. 446
Page end: p. 449
Abstract:
OBJECTIVE: To investigate the role of the Fc(alpha)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(alpha)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(alpha)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

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