Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer
until further notice
SourceThe Journal of Infectious Diseases, 203, 8, (2011), pp. 1101-1109
Article / Letter to editor
Display more detailsDisplay less details
Laboratory of Genetic, Endocrine and Metabolic Diseases
Paediatrics - OUD tm 2017
The Journal of Infectious Diseases
SubjectIGMD 7: Iron metabolism N4i 1: Pathogenesis and modulation of inflammation; N4i 1 - pathogenesis and modulation of inflammation Oncol 5 - Aetiology, screening and detection; N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity; ONCOL 5: Aetiology, screening and detection N4i 1: Pathogenesis and modulation of inflammation
BACKGROUND: The prevalence of Streptococcus gallolyticus subsp gallolyticus ( Streptococcus bovis biotype I) endocarditis is in general low but very often linked to colorectal cancer. Therefore, this study aimed to reveal the virulence characteristics that distinguish this opportunistic pathogen from a panel of (closely related) intestinal bacteria. METHODS: The route of infection was reconstructed in vitro with adhesion, invasion, and translocation assays on differentiated Caco-2 cells. Furthermore, cellular immune responses upon infection and bacterial biofilm formation were analyzed in a comparative manner. RESULTS: S. gallolyticus subsp gallolyticus strains were demonstrated to have a relative low adhesiveness and could not internalize epithelial cells. However, these bacteria were uniquely able to paracellularly cross a differentiated epithelium without inducing epithelial interleukin 8 or 1beta responses. Importantly, they had an outstanding ability to form biofilms on collagen-rich surfaces, which in vivo are found at damaged heart valves and (pre)cancerous sites with a displaced epithelium. CONCLUSIONS: Together, these data show that S. gallolyticus subsp gallolyticus has a unique repertoire of virulence factors that facilitate infection through (pre)malignant colonic lesions and subsequently can provide this bacterium with a competitive advantage in (1) evading the innate immune system and (2) forming resistant vegetations at collagen-rich sites in susceptible patients with colorectal cancer.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.