Contribution of different local vascular responses to mid-gestational vasodilation
until further notice
SourceAmerican Journal of Obstetrics and Gynecology, 205, 2, (2011), pp. 155 e12-7
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
American Journal of Obstetrics and Gynecology
p. 155 e12
SubjectIGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection; NCEBP 14: Cardiovascular diseases; NCEBP 14: Cardiovascular diseases IGMD 6: Hormonal regulation
OBJECTIVE: At-term pregnancy-induced vasodilation is the resultant of endothelium-dependent vasodilation, decreased myogenic reactivity, increased compliance, and reduced sensitivity to vasoconstrictor agents. We hypothesized that these vascular changes are already present at mid-gestation. STUDY DESIGN: In 20 mid-pregnant and 20 nonpregnant Wistar Hannover rats, we measured vascular responses of isolated mesenteric arteries and kidney. RESULTS: In the pregnant rats compared with the nonpregnant rats, mesenteric flow-mediated vasodilation and renal perfusion flow increased 1.52-fold (from 47 +/- 5 to 31 +/- 4 muL/min) and 1.13-fold (from 12.8 +/- 0.1 to 14.4 +/- 0.1 mL/min), respectively. Nitric oxide inhibition reduced mesenteric flow-mediated vasodilation to a similar extent in the pregnant and nonpregnant rats; it completely blocked the pregnancy-induced increase in renal perfusion flow. Pregnancy did not change mesenteric artery sensitivity to phenylephrine, myogenic reactivity, nor vascular compliance. CONCLUSION: At mid-gestation, alterations in rat mesenteric vascular tone depend primarily on flow-mediated endothelium-dependent changes and not on changes in alpha-adrenergic vasoconstrictor sensitivity, myogenic reactivity, or vascular compliance.
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