Automatic breast density segmentation: an integration of different approaches
SourcePhysics in Medicine and Biology, 56, 9, (2011), pp. 2715-2729
Article / Letter to editor
Display more detailsDisplay less details
Epidemiology, Biostatistics & HTA
Physics in Medicine and Biology
SubjectONCOL 5: Aetiology, screening and detection
Mammographic breast density has been found to be a strong risk factor for breast cancer. In most studies, it is assessed with a user-assisted threshold method, which is time consuming and subjective. In this study, we develop a breast density segmentation method that is fully automatic. The method is based on pixel classification in which different approaches known in the literature to segment breast density are integrated and extended. In addition, the method incorporates the knowledge of a trained observer, by using segmentations obtained by the user-assisted threshold method as training data. The method is trained and tested using 1300 digitized film mammographic images acquired with a variety of systems. Results show a high correspondence between the automated method and the user-assisted threshold method. Pearson's correlation coefficient between our method and the user-assisted method is R = 0.911 for percent density and R = 0.895 for dense area, which is substantially higher than the best correlation found in the literature (R = 0.70, R = 0.68). The area under the receiver operating characteristic curve obtained when discriminating between fatty and dense pixels is 0.987. A combination of segmentation strategies outperforms the application of single segmentation techniques.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.