Automatic breast density segmentation: an integration of different approaches
Publication year
2011Source
Physics in Medicine and Biology, 56, 9, (2011), pp. 2715-29ISSN
Publication type
Article / Letter to editor
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Organization
Radiology
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Physics in Medicine and Biology
Volume
vol. 56
Issue
iss. 9
Page start
p. 2715
Page end
p. 29
Subject
ONCOL 5: Aetiology, screening and detection; Medical Imaging - Radboud University Medical CenterAbstract
Mammographic breast density has been found to be a strong risk factor for breast cancer. In most studies, it is assessed with a user-assisted threshold method, which is time consuming and subjective. In this study, we develop a breast density segmentation method that is fully automatic. The method is based on pixel classification in which different approaches known in the literature to segment breast density are integrated and extended. In addition, the method incorporates the knowledge of a trained observer, by using segmentations obtained by the user-assisted threshold method as training data. The method is trained and tested using 1300 digitized film mammographic images acquired with a variety of systems. Results show a high correspondence between the automated method and the user-assisted threshold method. Pearson's correlation coefficient between our method and the user-assisted method is R = 0.911 for percent density and R = 0.895 for dense area, which is substantially higher than the best correlation found in the literature (R = 0.70, R = 0.68). The area under the receiver operating characteristic curve obtained when discriminating between fatty and dense pixels is 0.987. A combination of segmentation strategies outperforms the application of single segmentation techniques.
This item appears in the following Collection(s)
- Academic publications [246326]
- Faculty of Medical Sciences [93294]
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