TREM-1 interaction with the LPS/TLR4 receptor complex

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Title:	TREM-1 interaction with the LPS/TLR4 receptor complex
Author(s):	Arts, R.J.; Joosten, L.A.B. ; Dinarello, C.A. ; Kullberg, B.J. ; Meer, J.W.M. van der ; Netea, M.G.
Publication year:	2011
Source:	European Cytokine Network, vol. 22, iss. 1, (2011), pp. 11-14
ISSN:	1148-5493
DOI:	https://doi.org/10.1684/ecn.2011.0274
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/97391
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Subject:	N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity
Organization:	Internal Medicine
Journal title:	European Cytokine Network
Volume:	vol. 22
Issue:	iss. 1
Page start:	p. 11
Page end:	p. 14
Abstract:	Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors. In this study, several lines of evidence are presented that TREM-1 interacts with the toll-like receptor 4 (TLR4) receptor complex, or is a component of this complex. Blocking anti-TREM-1 antibodies specifically inhibited LPS-induced TNF-alpha production, while the alternative approach of blocking TLR4 by a specific inhibitor led to a down-regulation of the effects of TREM-1 cross-linking. These data are in line with the TLR4-TREM1 co-localization in human neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with the TLR4/LPS-receptor complex.