Publication year
2011Source
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35, 2, (2011), pp. 554-560ISSN
Publication type
Article / Letter to editor

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Organization
PI Group Memory and Emotion
Cognitive Neuroscience
Former Organization
F.C. Donders Centre for Cognitive Neuroimaging
Journal title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume
vol. 35
Issue
iss. 2
Page start
p. 554
Page end
p. 560
Subject
110 012 Social cognition of verbal communication; 150 000 MR Techniques in Brain Function; DCN 1: Perception and Actions NCEBP 9: Mental HealthAbstract
BACKGROUND: We conducted a post-hoc analysis of the Long-Acting MethylpheniDate in Adult attention-deficit hyperactivity disorder (LAMDA) study to investigate predictors of response in adults with ADHD randomly assigned to Osmotic Release Oral System (OROS)((R))-methylphenidate hydrochloride (MPH) 18, 36 or 72 mg or placebo. METHODS: LAMDA comprised a 5-week, double-blind (DB) period, followed by a 7-week, open-label (OL) period. A post-hoc analysis of covariance and a logistic regression analysis were undertaken to detect whether specific baseline parameters or overall treatment compliance during the double-blind phase contributed to response. The initial model included all covariates as independent variables; a backward stepwise selection method was used, with stay criteria of p<0.10. Six outcomes were considered: change from baseline CAARS:O-SV (physician-rated) and CAARS:S-S (self-report) scores at DB and OL end points, and response rate (>/=30% decrease in CAARS:O-SV score from baseline) and normalization of CAARS:O-SV score at DB end point. RESULTS: Taking into account a significant effect of OROS((R))-MPH treatment versus placebo in the original analysis (p</=0.015), across the outcomes considered in this post-hoc analysis, higher baseline CAARS scores were most strongly predictive of superior outcomes. Male gender and lower academic achievement were also predictive for improved results with certain outcomes. CONCLUSIONS: Several baseline factors may help to predict better treatment outcomes in adults receiving OROS((R))-MPH; however, further research is required to confirm these findings and examine their neurobiological underpinnings.
This item appears in the following Collection(s)
- Academic publications [202923]
- Donders Centre for Cognitive Neuroimaging [3357]
- Faculty of Medical Sciences [80072]
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