In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing

There is no fulltext present in this item.

Title:	In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
Author(s):	Rudramurthy, S.M.; Chakrabarti, A.; Geertsen, E.; Mouton, J.W.; Meis, J.F.G.M.
Publication year:	2011
Source:	Diagnostic Microbiology and Infectious Diseases, vol. 71, iss. 4, (2011), pp. 370-377
ISSN:	0732-8893
DOI:	https://doi.org/10.1016/j.diagmicrobio.2011.08.006
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/97028
Display more details
Subject:	N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity NCMLS 2: Immune Regulation
Organization:	Biochemistry (UMC) Medical Microbiology
Journal title:	Diagnostic Microbiology and Infectious Diseases
Volume:	vol. 71
Issue:	iss. 4
Page start:	p. 370
Page end:	p. 377
Abstract:	Aspergillus flavus is the second most common species causing invasive aspergillosis after A. fumigatus. In certain countries like India, Sudan, and Saudi Arabia, A. flavus is most frequently isolated from patients with fungal rhinosinusitis and endophthalmitis. A. flavus exhibit an increased resistance to antifungal agents compared to A. fumigatus. We determined the in vitro activity of isavuconazole, voriconazole, posaconazole, itraconazole, amphotericin B, caspofungin, micafungin, and anidulafungin against 208 isolates of A. flavus by the EUCAST method and compared with the results obtained by the CLSI method. Isavuconazole and voriconazole MICs were </=2 mug/mL in 99% and 95%, respectively. Posaconazole and itraconazole MICs were </=0.5 and </=1 mug/mL, respectively, for all isolates. MICs of amphotericin B were >/=2 mug/mL in 91%; 36% of them exhibited MICs of >/=8 mug/mL. All echinocandins demonstrated good anti-A. flavus activity. The essential agreement of the MIC/MEC results by EUCAST with CLSI broth dilution method assessed at +/-2 dilutions was good for itraconazole (97.8%), voriconazole (100%), posaconazole (98.3%), isavuconazole (98.9%), caspofungin (99.4%), and anidulafungin (100%), but poor for amphotericin B (53.5%) and micafungin (79.1%).