IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and herpes simplex virus-1
Publication year
2011Source
Journal of Investigative Dermatology, 131, 4, (2011), pp. 900-6ISSN
Publication type
Article / Letter to editor
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Organization
Tumorimmunology
Medical Oncology
Paediatrics - OUD tm 2017
Journal title
Journal of Investigative Dermatology
Volume
vol. 131
Issue
iss. 4
Page start
p. 900
Page end
p. 6
Subject
NCMLS 2: Immune Regulation ONCOL 3: Translational research; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research NCMLS 2: Immune RegulationAbstract
Human plasmacytoid dendritic cells (pDCs) are found in skin lesions in a wide variety of diseases. The role of the microenvironment in these lesions on the function of human pDCs remains elusive. We sought to determine the effect of T(h)2 cytokines on the ability of human pDCs to respond to CpG oligodeoxynucleotides (ODNs) and herpes simplex virus in vitro. In this study, we found that the T(h)2 cytokines, IL-4 and IL-13, modulate Toll-like receptor 9 (TLR-9)- and herpes simplex virus-induced pDC phenotype and enhance the ability of these cells to induce allogeneic T-cell responses. Moreover, T(h)2 cytokines impaired TLR-9-induced secretion of inflammatory cytokines and chemokines. Taken together, these results demonstrate that T(h)2 cytokines are involved in the modulation of pDC function and responsiveness to bacterial- and viral-derived stimuli.
This item appears in the following Collection(s)
- Academic publications [238426]
- Electronic publications [122508]
- Faculty of Medical Sciences [90358]
- Open Access publications [97504]
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