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Title: Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole
Author(s): Kuipers, S.; Bruggemann, R.J.M. ; Sevaux, R.G. de ; Heesakkers, J.P.F.A. ; Melchers, W.J.G. ; Mouton, J.W.; Verweij, P.E.
Publication year: 2011
Source: Antimicrobial Agents and Chemotherapy, vol. 55, iss. 7, (2011), pp. 3564-3566
ISSN: 0066-4804
DOI: http://dx.doi.org/10.1128/AAC.01544-10
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/96921   http://hdl.handle.net/2066/96921

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Subject: N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity
N4i 2: Invasive mycoses and compromised host
N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international health
N4i 4: Auto-immunity, transplantation and immunotherapy
NCEBP 2: Evaluation of complex medical interventions
Organization: Clinical Pharmacy
Nephrology
Urology
Medical Microbiology
Journal title:
Antimicrobial Agents and Chemotherapy
Volume: vol. 55
Issue: iss. 7
Page start: p. 3564
Page end: p. 3566
Abstract:
We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.

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