Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole

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Publication year
2011Source
Antimicrobial Agents and Chemotherapy, 55, 7, (2011), pp. 3564-3566ISSN
Publication type
Article / Letter to editor

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Organization
Clinical Pharmacy
Nephrology
Urology
Medical Microbiology
Journal title
Antimicrobial Agents and Chemotherapy
Volume
vol. 55
Issue
iss. 7
Page start
p. 3564
Page end
p. 3566
Subject
N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity; N4i 2: Invasive mycoses and compromised host; N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international health; N4i 4: Auto-immunity, transplantation and immunotherapy; NCEBP 2: Evaluation of complex medical interventionsAbstract
We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.
This item appears in the following Collection(s)
- Academic publications [204951]
- Electronic publications [103216]
- Faculty of Medical Sciences [81049]
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