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Publication year
2011Source
Diabetes, Obesity & Metabolism, 13, 4, (2011), pp. 382-4ISSN
Publication type
Article / Letter to editor

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Organization
Paediatrics - OUD tm 2017
Physiology
IQ Healthcare
Rehabilitation
Journal title
Diabetes, Obesity & Metabolism
Volume
vol. 13
Issue
iss. 4
Page start
p. 382
Page end
p. 4
Subject
IGMD 8: Mitochondrial medicine; NCEBP 10: Human Movement & Fatigue; NCEBP 14: Cardiovascular diseases IGMD 5: Health aging / healthy living; NCEBP 6: Quality of nursing and allied health care; NCEBP 6: Quality of nursing and allied health careAbstract
Children with type 1 diabetes mellitus (DM1) show endothelial dysfunction and mild artery wall thickening compared to their age-matched healthy peers. In this study, we examined the effect of 18-week exercise training on physical fitness and vascular function and structure in children with DM1. We examined physical fitness, brachial artery endothelial function [flow-mediated dilation (FMD)], common carotid artery diameter, wall thickness and wall-to-lumen ratio before and after 18-week exercise training in children with DM1 (n = 7). Physical fitness, measured as maximal oxygen consumption, improved after training (p = 0.039). Brachial artery FMD improved from 7.5 +/- 4.2 to 12.4 +/- 5.2 (p = 0.038). Carotid artery diameter, wall thickness and wall-to-lumen ratio did not change significantly (p = 0.26, 0.53 and 0.27, respectively). We showed that exercise training in children with DM1 effectively reverses endothelial dysfunction and improves physical fitness. These data emphasize the important role for physical activity in the management of DM1.
This item appears in the following Collection(s)
- Academic publications [203608]
- Electronic publications [101974]
- Faculty of Medical Sciences [80231]
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