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Publication year
2011Source
Radiotherapy and Oncology, 98, 2, (2011), pp. 203-206ISSN
Annotation
van Tol-Geerdink, Julia J Leer, Jan Willem van Lin, Emile N J T Schimmel, Erik C Stalmeier, Peep F M Research Support, Non-U.S. Gov't Ireland Radiother Oncol. 2011 Feb;98(2):203-6. Epub 2011 Jan 20.
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
UMCN Extern
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Radiotherapy and Oncology
Volume
vol. 98
Issue
iss. 2
Page start
p. 203
Page end
p. 206
Subject
NCEBP 2:Evaluation of complex medical interventions ONCOL 4:Quality of Care; ONCOL 4: Quality of Care; ONCOL 5: Aetiology, screening and detectionAbstract
BACKGROUND: We studied whether hormonal therapy, (neo)adjuvant to radiotherapy for localized prostate cancer, is related to an increase in depression and whether this is caused by the hormonal therapy itself or by the relatively poor prognosis of patients who get (neo)adjuvant hormonal therapy. METHODS: Between 2002 and 2005, 288 patients, irradiated for prostate cancer (T1-3N0M0), were studied prospectively in two clinics. In one clinic almost all patients received (neo)adjuvant androgen deprivation (Bicalutamide+Gosereline). In a second clinic hormonal therapy was prescribed mainly for high risk patients. This allowed us to separate the effects of hormonal therapy and the patient's prognosis. RESULTS: During the course of hormonal therapy, depression was significantly heightened by both hormone use (p<0.001) and poor prognosis (p<0.01). After completion of hormonal therapy, poor prognosis continued to affect the depression score (p<0.01). The increase was, however, small. CONCLUSIONS: Depression was mildly increased in patients receiving hormonal therapy. The increase appeared to be related to both the hormone therapy itself and the high risk status of patients. High risk status, with the associated poor prognosis, had a more sustained effect on depression. The rise was statistically significant, but was too small, however, to bear clinical significance.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
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