Deciphering the genetic background of systemic sclerosis
SourceExpert Review of Clinical Immunology, 7, 4, (2011), pp. 449-62
Article / Letter to editor
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Expert Review of Clinical Immunology
SubjectIGMD 3: Genomic disorders and inherited multi-system disorders NCEBP 1: Molecular epidemiology; NCMLS 1: Infection and autoimmunity N4i 4: Auto-immunity, transplantation and immunotherapy
Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.
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- Academic publications 
- Faculty of Medical Sciences 
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