CSF alpha-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid beta in humans
until further notice
SourceNeuroscience Letters, 504, 3, (2011), pp. 336-338
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
SubjectDCN 1: Perception and Action NCEBP 11: Alzheimer Centre; DCN 2: Functional Neurogenomics; NCEBP 14: Cardiovascular diseases
Reports on the value of cerebrospinal fluid (CSF) alpha-synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF alpha-synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid beta concentrations. Furthermore, a physiological relationship between alpha-synuclein and amyloid beta has been suggested based on in vitro research. We performed repeated CSF sampling in healthy elderly and AD patients and showed that sinusoidal fluctuations in CSF alpha-synuclein concentrations were not present. Furthermore, we did not find evidence for an interaction between amyloid beta and alpha-synuclein concentrations in CSF.
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