A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease
until further notice
SourcePediatric Infectious Disease Journal, 30, 9, (2011), pp. 794-797
Article / Letter to editor
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Pediatric Infectious Disease Journal
SubjectN4i 2: Invasive mycoses and compromised host; N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international health; N4i 4: Auto-immunity, transplantation and immunotherapy
Posaconazole (PSZ) may be an attractive alternative for antifungal prophylaxis in children with chronic granulomatous disease. Experience with PSZ in pediatric patients is limited, and no specific dose recommendations exist. A twice daily dosing algorithm based on allometric scaling (body-weight based) for PSZ results in adequate exposure and appears to be safe in children with chronic granulomatous disease.
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