A toxic shot from the hip
until further notice
SourceJournal of Neurology, Neurosurgery, and Psychiatry, 82, 3, (2011), pp. 353-354
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal of Neurology, Neurosurgery, and Psychiatry
SubjectDCN 2: Functional Neurogenomics NCEBP 10: Human Movement & Fatigue; IGMD 7: Iron metabolism N4i 1: Pathogenesis and modulation of inflammation
A 26-year-old man developed a movement disorder characterised by bradyphrenia, bradykinesia, rigidity, tremor and dystonia, several years after having been shot by a gun in the hip. Laboratory investigations revealed anaemia and porphyria. The authors demonstrate that his neurological condition was a delayed manifestation of lead toxicity, caused by slow absorption of lead from persisting bullet fragments in the hip joint. Treatment with excision of the femoral head and debridement of the hip followed by a total hip, in combination with chelating therapy, led to a remarkable remission.
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