A novel and automatic mammographic texture resemblance marker is an independent risk factor for breast cancer
Publication year
2011Source
Cancer Epidemiology, 35, 4, (2011), pp. 381-7ISSN
Publication type
Article / Letter to editor
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Organization
Radiology
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Cancer Epidemiology
Volume
vol. 35
Issue
iss. 4
Page start
p. 381
Page end
p. 7
Subject
NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection; ONCOL 5: Aetiology, screening and detection; Medical Imaging - Radboud University Medical CenterAbstract
OBJECTIVE: We investigated whether breast cancer is predicted by a breast cancer risk mammographic texture resemblance (MTR) marker. METHODS: A previously published case-control study included 495 women of which 245 were diagnosed with breast cancer. In baseline mammograms, 2-4 years prior to diagnosis, the following mammographic parameters were analysed for relation to breast cancer risk: (C) categorical parenchymal pattern scores; (R) radiologist's percentage density, (P) computer-based percentage density; (H) computer-based breast cancer risk MTR marker; (E) computer-based hormone replacement treatment MTR marker; and (A) an aggregate of P and H. RESULTS: Density scores, C, R, and P correlated (tau=0.3-0.6); no other pair of scores showed large (tau>0.2) correlation. For the parameters, the odds ratios of future incidence of breast cancer comparing highest to lowest categories (146 and 106 subject respectively) were C: 2.4(1.4-4.2), R: 2.4(1.4-4.1), P: 2.5(1.5-4.2), E: non-significant, H: 4.2(2.4-7.2), and A: 5.6(3.2-9.8). The AUC analysis showed a similarly increasing pattern (C: 0.58+/-0.02, R: 0.57+/-0.03, P: 0.60+/-0.03, H: 0.63+/-0.02, A: 0.66+/-0.02). The AUC of the aggregate marker (A) surpasses others significantly except H. HRT-MTR (E) did not significantly identify future cancers or correlate with any other marker. CONCLUSIONS: Breast cancer risk MTR marker was independent of density scores and more predictive of risk. The hormone replacement treatment MTR marker did not identify patients at risk.
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- Academic publications [245050]
- Faculty of Medical Sciences [93209]
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