Reference values for myocardial two-dimensional strain echocardiography in a healthy pediatric and young adult cohort
Publication year
2011Source
Journal of the American Society of Echocardiography, 24, 6, (2011), pp. 625-36ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Paediatrics - OUD tm 2017
Cardiology
Health Evidence
Radiology
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Journal of the American Society of Echocardiography
Volume
vol. 24
Issue
iss. 6
Page start
p. 625
Page end
p. 36
Subject
IGMD 1: Functional imaging; IGMD 5: Health aging / healthy living; NCEBP 14: Cardiovascular diseases; NCEBP 2: Evaluation of complex medical interventions; ONCOL 2: Age-related aspects of cancer; IGMD 1: Functional imaging NCEBP 14: Cardiovascular diseasesAbstract
BACKGROUND: The accurate evaluation of intrinsic myocardial contractility in children with or without congenital heart disease (CHD) has turned out to be a challenge. Two-dimensional strain echocardiographic (2DSTE) imaging or two-dimensional speckle-tracking echocardiographic imaging appears to hold significant promise as a tool to improve the assessment of ventricular myocardial function. The aim of this study was to estimate left ventricular myocardial systolic function using 2DSTE imaging in a large cohort consisting of healthy children and young adults to establish reference strain values. METHODS: Transthoracic echocardiograms were acquired in 195 healthy subjects (139 children, 56 young adults) and were retrospectively analyzed. Longitudinal, circumferential, and radial peak systolic strain values were determined by means of speckle tracking. Nonlinear regression analysis was performed to assess the effect of aging on these 2DSTE parameters. RESULTS: There was a strong, statistically significant second-order polynomial relation (P < .001) between global peak systolic strain parameters and age. Global peak systolic strain values were lowest in the youngest and oldest age groups. CONCLUSION: This is the first report to establish age-dependent reference values per cardiac segment for myocardial strain in all three directions assessed using 2DSTE imaging in a large pediatric and young adult cohort. There is a need to use age-specific reference values for the adequate interpretation of 2DSTE measurements.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.