Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses
SourceMolecular Immunology, 48, 6-7, (2011), pp. 810-7
Article / Letter to editor
Display more detailsDisplay less details
Paediatrics - OUD tm 2017
SubjectNCMLS 2: Immune Regulation ONCOL 3: Translational research; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research NCMLS 2: Immune Regulation
Synthetic oligonucleotide ligands that bind to toll-like receptors are known to modulate the immune response via the activation of antigen presenting cells, and were therefore proposed as a novel form of vaccine adjuvant. Clinical-grade they are, however, not readily available. Here, we show that commonly used prophylactic vaccines for infectious diseases like measles, mumps and tuberculosis exhibit the same immune modulating behavior as synthetic CpG oligonucleotides in terms of their ability to stimulate IFN-alpha production and plasmacytoid dendritic cell maturation. Featuring the additional advantages of low-cost and proven safety, these vaccines could therefore be attractive alternatives to CpG oligonucleotides as adjuvants for immunotherapy. This previously undiscovered characteristic of prophylactic vaccines also sheds new light on the mechanisms by which they operate and is extremely interesting for vaccine development. Moreover, the finding that prophylactic vaccines trigger TLRs like synthetic oligonucleotides opens the possibility to predict the immune response of new vaccines.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.