Potential risk factors for developing heterotopic ossification in patients with severe traumatic brain injury
Publication year
2011Source
Journal of Head Trauma Rehabilitation, 26, 5, (2011), pp. 384-91ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Intensive Care
Rehabilitation
Journal title
Journal of Head Trauma Rehabilitation
Volume
vol. 26
Issue
iss. 5
Page start
p. 384
Page end
p. 91
Subject
DCN 3: Neuroinformatics; N4i 1: Pathogenesis and modulation of inflammation; NCEBP 10: Human Movement & FatigueAbstract
BACKGROUND: Heterotopic ossification (HO) is a frequent complication after traumatic brain injury (TBI). The current preliminary study is intended to provide additional data on the potential roles that brain injury severity, concomitant orthopaedic trauma, and specific intensive care complicating events may play in the prediction of HO in patients who have sustained severe TBI. METHODS: A prospective cohort study in patients with severe TBI. RESULTS: Ninety-seven of the 176 patients were eligible for follow-up; 13 patients (13%) developed 19 clinically relevant HOs at 1 or more sites. Univariate analysis indicated that patients with HO remained in coma longer (P < .001) and were ventilated during a longer period (P = .002). Autonomic dysregulation (relative risk = 6.11, 95% confidence interval: 2.53-14.76) and surgically treated extremity fractures (relative risk = 5.02, 95% confidence interval: 1.68-15.04) also showed significant associations with the development of HO. CONCLUSION: Prolonged coma duration and mechanical ventilation, coexistent surgically treated bone fractures and clinical signs of autonomic dysregulation should be given further consideration as potential risk factors for developing clinically relevant HO. Larger-scale studies are needed to develop a valid risk profile that takes into account the interrelationships between variables.
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- Academic publications [227695]
- Faculty of Medical Sciences [87091]
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