Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease

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Publication year
2011Source
Stroke, 42, 2, (2011), pp. 494-7ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Geriatrics
IQ Healthcare
Journal title
Stroke
Volume
vol. 42
Issue
iss. 2
Page start
p. 494
Page end
p. 7
Subject
DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics NCEBP 9: Mental health; NCEBP 11: Alzheimer Centre; NCEBP 14: Cardiovascular diseasesAbstract
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD), including white matter lesions and lacunar infarcts, is related to gait disturbances. Microbleeds (MB) are another manifestation of SVD, but their clinical impact remains unclear. We therefore investigated the relation between the number and location of MB and gait, independently of white matter lesions and lacunar infarcts. METHODS: MRI scanning was performed in 485 nondemented elderly individuals with cerebral SVD. The number and location of MB were rated. Gait was assessed with a GAITRite system and the Tinetti and Timed-Up-and-Go tests. MB were related to gait parameters by age, height, total brain volume, white matter lesions, and number of lacunar infarcts-adjusted linear regression. RESULTS: A higher number of MB was independently related to a shorter stride length and poorer performance on the Tinetti and Timed-Up-and-Go tests. These relations seemed to be explained by MB in the temporal and frontal lobe and basal ganglia, including the thalamus. CONCLUSIONS: This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.
This item appears in the following Collection(s)
- Academic publications [227613]
- Electronic publications [107286]
- Faculty of Medical Sciences [86193]
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