Dopamine susceptibility of APO-SUS rats is not per se coupled to HPA-axis activity
until further notice
SourcePhysiology and Behavior, 102, 2, (2011), pp. 121-125
Article / Letter to editor
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Molecular Animal Physiology
Laboratory of Genetic, Endocrine and Metabolic Diseases
Physiology and Behavior
SubjectDCN 3: Neuroinformatics; IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection; Molecular Animal Physiology
A synergistic relationship is thought to exist between hypothalamic-pituitary-adrenal (HPA) axis activity and dopamine neurotransmission. To test whether a high response to dopamine indeed implies a hyperactive HPA-axis, we here used Wistar rats that were selected twice independently (original and replicate lines) for a high or low susceptibility to the dopamine receptor agonist apomorphine (so-called APO-SUS and APO-UNSUS rats, respectively). The APO-SUS rats from the original line displayed a hyperactive HPA-axis in that higher basal and stress-induced adrenocorticotropic hormone (ACTH) levels, and lower basal free-corticosterone levels were observed than those found in the original APO-UNSUS rats. In contrast, the activity of the HPA-axis in the APO-SUS rats from the replicate line did not differ from that in the replicate APO-UNSUS rats. Thus, in the APO-SUS/APO-UNSUS rat model the level of HPA-axis activity is not necessarily causally linked to dopamine responsiveness, implying that a hyperactive HPA-axis is not a prerequisite for a high dopaminergic response.
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