Congenital diaphragmatic hernia: still a moving target

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Title:	Congenital diaphragmatic hernia: still a moving target
Author(s):	Sluiter, I.; Ven, C.P. van de; Wijnen, R.M.H. ; Tibboel, D.
Publication year:	2011
Source:	Seminars in Fetal & Neonatal Medicine, vol. 16, iss. 3, (2011), pp. 139-144
ISSN:	1744-165X
DOI:	https://doi.org/10.1016/j.siny.2011.03.002
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/95754
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Subject:	IGMD 3: Genomic disorders and inherited multi-system disorders
Organization:	Paediatrics
Journal title:	Seminars in Fetal & Neonatal Medicine
Volume:	vol. 16
Issue:	iss. 3
Page start:	p. 139
Page end:	p. 144
Abstract:	The primary therapeutic target for congenital diaphragmatic hernia (CDH) patients has shifted from emergency surgical repair towards a non-operative emergency of the newborn treated by interdisciplinary teams. The increased understanding of the epidemiological and pathophysiological aspects of CDH have led to an improved knowledge and application of prenatal diagnosis, postnatal ventilation strategies, treatment of associated pulmonary hypertension and the role of extracorporeal membrane oxygenation therapy. In the surgical field, the perspectives have changed with delayed CDH repair, the introduction of minimally invasive surgery and use of prosthetic material for closure of large defects. With decreased mortality, long term multi-organ morbidity has increased in some survivors. In the near future, randomized controlled trials on different aspects of therapy will determine evidence-based optimal care.