Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.

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Title:	Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.
Author(s):	Alam, M.T.; Medema, M.H.; Takano, E.; Breitling, R.
Publication year:	2011
Source:	Febs Letters, vol. 585, iss. 14, (2011), pp. 2389-2394
ISSN:	1873-3468
DOI:	https://doi.org/10.1016/j.febslet.2011.06.014
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/95740
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Subject:	NCMLS 4: Energy and redox metabolism
Organization:	Biochemistry (UMC)
Journal title:	Febs Letters
Volume:	vol. 585
Issue:	iss. 14
Page start:	p. 2389
Page end:	p. 2394
Abstract:	Actinomycetes are highly important bacteria. On one hand, some of them cause severe human and plant diseases, on the other hand, many species are known for their ability to produce antibiotics. Here we report the results of a comparative analysis of genome-scale metabolic models of 37 species of actinomycetes. Based on in silico knockouts we generated topological and genomic maps for each organism. Combining the collection of genome-wide models, we constructed a global enzyme association network to identify both a conserved "core network" and an "essential core network" of the entire group. As has been reported for low-degree metabolites in several organisms, low-degree enzymes (in linear pathways) turn out to be generally more essential than high-degree enzymes (in metabolic hubs).