Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.
Publication year
2011Source
FEBS Letters, 585, 14, (2011), pp. 2389-94ISSN
Publication type
Article / Letter to editor

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Organization
Biochemistry (UMC)
Journal title
FEBS Letters
Volume
vol. 585
Issue
iss. 14
Page start
p. 2389
Page end
p. 94
Subject
NCMLS 4: Energy and redox metabolismAbstract
Actinomycetes are highly important bacteria. On one hand, some of them cause severe human and plant diseases, on the other hand, many species are known for their ability to produce antibiotics. Here we report the results of a comparative analysis of genome-scale metabolic models of 37 species of actinomycetes. Based on in silico knockouts we generated topological and genomic maps for each organism. Combining the collection of genome-wide models, we constructed a global enzyme association network to identify both a conserved "core network" and an "essential core network" of the entire group. As has been reported for low-degree metabolites in several organisms, low-degree enzymes (in linear pathways) turn out to be generally more essential than high-degree enzymes (in metabolic hubs).
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- Academic publications [227864]
- Faculty of Medical Sciences [86218]
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