Publication year
2010Source
British Journal of Surgery, 97, 3, (2010), pp. 383-390ISSN
Annotation
1 maart 2010
Publication type
Article / Letter to editor

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Organization
Surgery
Journal title
British Journal of Surgery
Volume
vol. 97
Issue
iss. 3
Page start
p. 383
Page end
p. 390
Subject
ONCOL 4: Quality of CareAbstract
BACKGROUND: This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy. METHODS: All patients undergoing surgical treatment of rectal cancer and synchronous liver metastases between 2000 and 2007 were identified retrospectively from a prospectively collected database. Three approaches were followed: the classical staged, the simultaneous and the liver-first approach. RESULTS: Of 57 patients identified, the primary tumour was resected first in 29 patients (group 1), simultaneous resection was performed in eight patients (group 2), and 20 patients underwent a liver-first approach (group 3). The overall morbidity rate was 24.6 per cent; there was no in-hospital mortality. Median in-hospital stay was significantly shorter for the simultaneous approach (9 days versus 18 and 15 days for groups 1 and 3 respectively; P < 0.001). The overall 5-year survival rate was 38 per cent, with an estimated median survival of 47 months. CONCLUSION: Long-term survival can be achieved using an individualized approach, with curative intent, in patients with rectal cancer and synchronous liver metastases. Simultaneous resections as well as the liver-first approach are attractive alternatives to traditional staged resections.
This item appears in the following Collection(s)
- Academic publications [204859]
- Faculty of Medical Sciences [81031]
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