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Title: Opioid detoxification: from controlled clinical trial to clinical practice.
Author(s): Dijkstra, B.A.; Jong, C.A.J. de ; Wensing, M.J.P. ; Krabbe, P.F.M. ; Staak, C.P.F. van der
Publication year: 2010
Source: American Journal on Addictions, vol. 19, iss. 3, (2010), pp. 283-290
ISSN: 1055-0496
DOI: http://dx.doi.org/10.1111/j.1521-0391.2010.00033.x
Annotation: 1 mei 2010
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/89919   http://hdl.handle.net/2066/89919

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Subject: NCEBP 2: Evaluation of complex medical interventions
NCEBP 3: Implementation Science
ONCOL 4: Quality of Care
NCEBP 3: Implementation Science
Organization: Psychiatry
IQ Healthcare
Health Evidence
SW OZ BSI KLP
Former Organization: Epidemiology, Biostatistics & HTA
Journal title:
American Journal on Addictions
Volume: vol. 19
Issue: iss. 3
Page start: p. 283
Page end: p. 290
Abstract:
Controlled clinical trials have high internal validity but suffer from difficulties in external validity. This study evaluates the generalizability of the results of a controlled clinical trial on rapid detoxification in the everyday clinical practice of two addiction treatment centers. The results show that rapid detoxification in everyday practice differs with regard to patient characteristics, enrolment, and completion rates (86.8% vs. 100%). However, abstinence rates after rapid detoxification in the controlled clinical trial (61.8%) were generalizable to everyday clinical practice (59.0%). Implementation factors that may have influenced the results, such as referral problems and treatment delivery, are discussed.

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