(18)F-fluoro-L-thymidine-PET for the evaluation of primary brain tumours in children: a report of three cases.

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Publication year
2010Source
Nuclear Medicine Communications, 31, 6, (2010), pp. 482-7ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor

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Organization
Nuclear Medicine
Paediatrics - OUD tm 2017
Radiology
Journal title
Nuclear Medicine Communications
Volume
vol. 31
Issue
iss. 6
Page start
p. 482
Page end
p. 7
Subject
ONCOL 2: Age-related aspects of cancer; ONCOL 3: Translational researchAbstract
BACKGROUND: F-fluoro-L-thymidine (FLT) has been shown to be a useful PET tracer in the evaluation of brain tumours in adults. No studies of this modality in children with brain tumours, however, have been published. OBJECTIVE: In this report three children with brain tumours are presented in which FLT-PET was used for different diagnostic purposes, in addition to imaging with MRI and F-fluorodeoxyglucose-PET. The first patient showed that FLT-PET could be helpful in differentiating between infection and malignancy. In the second patient FLT-PET was used for differentiating recurrent disease from radiotherapy effects. In the third patient, in which biopsy was not possible, FLT-PET was used for the characterization of the tumour. CONCLUSION: These patients show that FLT-PET might be a useful modality in different stages of the evaluation of primary brain tumours in children. However, further research to determine the clinical value, relative to MRI and fluorodeoxyglucose-PET, is required before routine implementation of FLT-PET.
This item appears in the following Collection(s)
- Academic publications [227942]
- Electronic publications [107434]
- Faculty of Medical Sciences [86237]
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