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Publication year
2010Source
The Journal of Nuclear Medicine (1978), 51, 6, (2010), pp. 973-7ISSN
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01 juni 2010
Publication type
Article / Letter to editor

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Organization
Nuclear Medicine
Gynaecology
Journal title
The Journal of Nuclear Medicine (1978)
Volume
vol. 51
Issue
iss. 6
Page start
p. 973
Page end
p. 7
Subject
NCMLS 2: Immune Regulation; ONCOL 3: Translational researchAbstract
We determined the renal radiation dose of a series of (111)In-labeled peptides using animal SPECT. Because the animals' health deteriorated, renal toxicity was assessed. METHODS: Wild-type and megalin-deficient mice were imaged repeatedly at 3- to 6-wk intervals to quantify renal retention after injection of 40-50 MBq of (111)In-diethylenetriaminepentaacetic acid-labeled peptides (octreotide, exendin, octreotate, neurotensin, and minigastrin analogs), and the absorbed kidney radiation doses were estimated. Body weight, renal function parameters, and renal histology were determined at 16-20 wk after the first scan and compared with those in naive animals. RESULTS: Because of high renal retention, (111)In-diethylenetriaminepentaacetic acid-exendin-4 scans resulted in a 70-Gy kidney radiation dose in wild-type mice. Megalin-deficient kidneys received 20-40 Gy. The other peptides resulted in much lower renal doses. Kidney function monitoring indicated renal damage in imaged animals. CONCLUSION: Micro-SPECT enables longitudinal studies in 1 animal. However, long-term nephrotoxic effects may be induced after high renal radiation doses, even with (111)In-labeled radiotracers.
This item appears in the following Collection(s)
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- Electronic publications [107311]
- Faculty of Medical Sciences [86198]
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