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Publication year
2010Source
Nephrology, Dialysis, Transplantation, 25, 9, (2010), pp. 2839-43ISSN
Annotation
01 september 2010
Publication type
Article / Letter to editor

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Organization
Paediatrics - OUD tm 2017
Journal title
Nephrology, Dialysis, Transplantation
Volume
vol. 25
Issue
iss. 9
Page start
p. 2839
Page end
p. 43
Subject
IGMD 9: Renal disorder; NCMLS 5: Membrane transport and intracellular motilityAbstract
The nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare, recently recognized disorder in water balance affecting not only infants but also adults. A new molecular mechanism responsible for NSIAD has recently been identified: a gain of function of the arginine vasopressin (AVP) receptor type 2 (V2R), causing the constitutive activation of the receptor. Clinical presentation and laboratory findings of NSIAD resemble those of the syndrome of inappropriate secretion of antidiuretic hormone and consist of hyponatraemia, seizures and the lack of urinary dilution; however, the AVP levels in plasma are undetectable or very low. An elucidation of the pathophysiology of this syndrome will provide more insight into the action of AVP. An effective treatment of NSIAD is available. It consists of fluid restriction and administration of oral urea. Reported experience with furosemide treatment in NSIAD is still lacking.
This item appears in the following Collection(s)
- Academic publications [227436]
- Electronic publications [107269]
- Faculty of Medical Sciences [86157]
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