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Title: Nephrogenic syndrome of inappropriate antidiuresis.
Author(s): Levtchenko, E.N. ; Monnens, L.A.H.
Publication year: 2010
Source: Nephrology, Dialysis, Transplantation, vol. 25, iss. 9, (2010), pp. 2839-2843
ISSN: 0931-0509
DOI: https://doi.org/10.1093/ndt/gfq324
Annotation: 1 september 2010
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/89524   http://hdl.handle.net/2066/89524

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Subject: IGMD 9: Renal disorder
NCMLS 5: Membrane transport and intracellular motility
Organization: Paediatrics
Journal title:
Nephrology, Dialysis, Transplantation
Volume: vol. 25
Issue: iss. 9
Page start: p. 2839
Page end: p. 2843
Abstract:
The nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare, recently recognized disorder in water balance affecting not only infants but also adults. A new molecular mechanism responsible for NSIAD has recently been identified: a gain of function of the arginine vasopressin (AVP) receptor type 2 (V2R), causing the constitutive activation of the receptor. Clinical presentation and laboratory findings of NSIAD resemble those of the syndrome of inappropriate secretion of antidiuretic hormone and consist of hyponatraemia, seizures and the lack of urinary dilution; however, the AVP levels in plasma are undetectable or very low. An elucidation of the pathophysiology of this syndrome will provide more insight into the action of AVP. An effective treatment of NSIAD is available. It consists of fluid restriction and administration of oral urea. Reported experience with furosemide treatment in NSIAD is still lacking.

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