Mycoviruses: future therapeutic agents of invasive fungal infections in humans?
until further notice
SourceEuropean Journal of Clinical Microbiology and Infectious Diseases, 29, 7, (2010), pp. 755-763
1 juli 2010
Article / Letter to editor
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European Journal of Clinical Microbiology and Infectious Diseases
SubjectN4i 2: Invasive mycoses and compromised host
Invasive fungal infections are relatively common opportunistic infections in immunocompromised patients and are still associated with a high mortality rate. Furthermore, these infections are often complicated by resistance or refractoriness to current antimicrobial agents. Therefore, an urgent need exists for new therapeutic strategies based on the identification of new microbial targets and novel antimicrobial agents. One such hypothetical therapeutic strategy may involve the use of mycoviruses that are able to selectively infect fungi. Current knowledge of mycoviruses of human pathogenic fungi and the scope for using (recombinant) mycoviruses as future biological control agents are reviewed here.
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