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Title: Repulsion of superinfecting virions: a mechanism for rapid virus spread.
Author(s): Doceul, V.; Hollinshead, M.; Linden, L. van der ; Smith, G.L.
Publication year: 2010
Source: Science, vol. 327, iss. 5967, (2010), pp. 873-876
ISSN: 0036-8075
DOI: https://doi.org/10.1126/science.1183173
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/89405   http://hdl.handle.net/2066/89405

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Subject: N4i 1: Pathogenesis and modulation of inflammation
NCMLS 1: Infection and autoimmunity
Organization: Medical Microbiology
Journal title:
Science
Volume: vol. 327
Issue: iss. 5967
Page start: p. 873
Page end: p. 876
Abstract:
Viruses are thought to spread across susceptible cells through an iterative process of infection, replication, and release, so that the rate of spread is limited by replication kinetics. Here, we show that vaccinia virus spreads across one cell every 75 minutes, fourfold faster than its replication cycle would permit. To explain this phenomenon, we found that newly infected cells express two surface proteins that mark cells as infected and, via exploitation of cellular machinery, induce the repulsion of superinfecting virions away toward uninfected cells. Mechanistically, early expression of proteins A33 and A36 was critical for virion repulsion and rapid spread, and cells expressing these proteins repelled exogenous virions rapidly. Additional spreading mechanisms may exist for other viruses that also spread faster than predicted by replication kinetics.

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