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Publication year
2010Source
Science, 327, 5967, (2010), pp. 873-876ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Journal title
Science
Volume
vol. 327
Issue
iss. 5967
Page start
p. 873
Page end
p. 876
Subject
N4i 1: Pathogenesis and modulation of inflammation; NCMLS 1: Infection and autoimmunityAbstract
Viruses are thought to spread across susceptible cells through an iterative process of infection, replication, and release, so that the rate of spread is limited by replication kinetics. Here, we show that vaccinia virus spreads across one cell every 75 minutes, fourfold faster than its replication cycle would permit. To explain this phenomenon, we found that newly infected cells express two surface proteins that mark cells as infected and, via exploitation of cellular machinery, induce the repulsion of superinfecting virions away toward uninfected cells. Mechanistically, early expression of proteins A33 and A36 was critical for virion repulsion and rapid spread, and cells expressing these proteins repelled exogenous virions rapidly. Additional spreading mechanisms may exist for other viruses that also spread faster than predicted by replication kinetics.
This item appears in the following Collection(s)
- Academic publications [202563]
- Electronic publications [100732]
- Faculty of Medical Sciences [79925]
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