Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report.

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Publication year
2010Source
Human Reproduction, 25, 4, (2010), pp. 824-838ISSN
Annotation
1 april 2010
Publication type
Article / Letter to editor

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Organization
Gynaecology
Journal title
Human Reproduction
Volume
vol. 25
Issue
iss. 4
Page start
p. 824
Page end
p. 838
Subject
NCEBP 12: Human Reproduction; NCEBP 12: Human ReproductionAbstract
This article reports the results of the most recent in a series of EHSRE workshops designed to synthesize the current state of the field in Andrology and provide recommendations for future work (for details see Appendix). Its focus is on methods for detecting sperm DNA damage and potential application of new knowledge about sperm chromatin organization, vulnerability and repair to improve the diagnosis and treatment of clinical infertility associated with that damage. Equally important is the use and reliability of these tests to identify the extent to which environmental contaminants or pharmaceutical agents may contribute to the incidence of sperm DNA damage and male fertility problems. A working group (for workshop details, see Appendix) under the auspices of ESHRE met in May 2009 to assess the current knowledgebase and suggest future basic and clinical research directions. This document presents a synthesis of the working group's understanding of the recent literature and collective discussions on the current state of knowledge of sperm chromatin structure and function during fertilization. It highlights the biological, assay and clinical uncertainties that require further research and ends with a series of 5 key recommendations.
This item appears in the following Collection(s)
- Academic publications [202863]
- Electronic publications [101052]
- Faculty of Medical Sciences [80039]
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