The clinical efficacy of topical methyl-aminolevulinate photodynamic therapy in moderate to severe actinic keratoses of the face and scalp.
Publication year
2010Source
Journal of Dermatological Treatment, 21, 4, (2010), pp. 252-257ISSN
Annotation
1 juli 2010
Publication type
Article / Letter to editor

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Organization
Dermatology
Journal title
Journal of Dermatological Treatment
Volume
vol. 21
Issue
iss. 4
Page start
p. 252
Page end
p. 257
Subject
N4i 1: Pathogenesis and modulation of inflammationAbstract
INTRODUCTION: Since actinic keratoses (AKs) often appear in areas with field cancerization, photodynamic therapy (PDT) may have significant advantages over the standard treatment options. Objectives: Clinical efficacy of PDT with topical methyl aminolevulinate (MAL-PDT) in field cancerization was evaluated with respect to the number of AKs and photodamage. METHODS: A total of 14 patients with 223 AKs on the face or scalp were treated with MAL-PDT. Two treatments with a 3-monthly interval were given. At baseline, before the second treatment and 3 months after the end of therapy, the number of AKs were counted and photodamage was assessed with respect to skin roughness, hyperpigmentation, hypopigmentation, scarring, atrophy, telangiectasia and wrinkling. RESULTS: Complete clearance was reached in patients with a moderate degree of actinic damage, whereas a severe degree of field cancerization demonstrated only partial clearance. The global score for photodamage improved significantly. After the follow-up period, none of the patients reaching clearance had developed relapsing or new AKs. CONCLUSIONS: MAL-PDT induces a high clearance rate of AKs, dependent on the degree of field cancerization, with a good improvement in photodamage and prevention of developing new AKs. Thus, more PDT sessions are needed in patients with a severe degree of field cancerization.
This item appears in the following Collection(s)
- Academic publications [205104]
- Faculty of Medical Sciences [81055]
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