The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation.
until further notice
SourceObesity, 18, 11, (2010), pp. 2234-2236
1 november 2010
Article / Letter to editor
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SubjectIGMD 5: Health aging / healthy living; N4i 1: Pathogenesis and modulation of inflammation
Obesity is characterized by chronic low-grade inflammation originating from expanding adipose tissue. In the present study, we examined the adipogenic expression levels of IL-1F6 and IL-1F8, both members of the IL-1 family of cytokines, and their effects on adipose tissue gene expression. Although IL-1F6 is primarily present in adipose tissue resident macrophages and induced by inflammation, IL-1F8 is absent. IL-1F6, but not IL-1F8, reduces adipocyte differentiation, as shown by a significant decrease in PPARgamma gene expression. Finally, both IL-1F6 and IL-1F8 are able to induce inflammatory gene expression in mature adipocytes. In conclusion, we demonstrate for the first time that IL-1F6 is present in adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARgamma expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.
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