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Title: Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters.
Author(s): Olivier, J.D.A. ; Cools, A.R. ; Deen, P.M.T. ; Olivier, B. ; Ellenbroek, A.A.
Publication year: 2010
Source: European Journal of Pharmacology, vol. 629, iss. 1-3, (2010), pp. 7-11
ISSN: 0014-2999
DOI: http://dx.doi.org/10.1016/j.ejphar.2009.11.049
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/88862   http://hdl.handle.net/2066/88862

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Subject: DCN 2: Functional Neurogenomics
IGMD 9: Renal disorder
NCMLS 5: Membrane transport and intracellular motility
Organization: Cognitive Neuroscience
Physiology
Psychoneuropharmacology
Journal title:
European Journal of Pharmacology
Volume: vol. 629
Issue: iss. 1-3
Page start: p. 7
Page end: p. 11
Abstract:
To investigate whether life-long disturbed serotonin neurotransmission may result in adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress-induced hyperthermia were studied in serotonin transporter knockout rats. The noradrenalin transporter blocker atomoxetine was more effective in reducing stress-induced hyperthermia, induced by an injection, in serotonin transporter (SERT) knockout (SERT(-/-)) rats compared to SERT(+/+) rats. The dopamine transporter blocker GBR12909 increased the core body temperature in SERT(-/-) rats, and had no effect on the SERT(+/+) rats. Finally, the noradrenalin transporter together with dopamine transporter blocker bupropion was more effective in decreasing the stress of an injection in SERT(-/-) rats than in SERT(+/+) rats. These data suggest that the sensitivity of dopamine and noradrenalin receptors is changed in serotonin transporter knockout rats. The lack of the serotonin transporter in SERT(-/-) rats might reflect humans with a life-long disturbed serotonin system, making this rat a good model to study possible changes in dopaminergic and noradrenergic systems in psychiatric disorders.

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