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Publication year
2010Source
European Journal of Cancer, 46, 18, (2010), pp. 3137-40ISSN
Annotation
01 december 2010
Publication type
Article / Letter to editor

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Organization
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
European Journal of Cancer
Volume
vol. 46
Issue
iss. 18
Page start
p. 3137
Page end
p. 40
Subject
NCEBP 1: Molecular epidemiology; NCEBP 2: Evaluation of complex medical interventions; ONCOL 5: Aetiology, screening and detectionAbstract
BACKGROUND: The United Kingdom is currently moving the age limit for invitation in its national breast screening programme downwards from 50 to 47. In contrast, the US Preventive Services Task Force concluded that, because of borderline statistical significance on effectiveness of mammographic screening, the current evidence is insufficient to advise screening in women aged 40-49. MATERIAL AND METHODS: We designed a case-referent study to investigate the effect of biennial mammographic screening on breast cancer mortality for women in their forties. In Nijmegen, the Netherlands, screening started in 1975. A total of 272 breast cancer deaths were identified, and 1360 referents aged 40-69 were sampled from the population invited for screening. Effectiveness was estimated by calculating the odds ratio (OR) indicating the breast cancer death rate in screened versus unscreened women. RESULTS: In women aged 40-49, the effect of screening was OR = 0.50 (95% confidence interval (CI) = 0.30-0.82). This result is similar to those aged 50-59 (OR = 0.54; 95% CI = 0.35-0.85) and 60-69 (OR = 0.65; 95% CI = 0.38-1.13). CONCLUSION: Our results add convincing evidence about the effectiveness of biennial mammographic screening in women aged 40-49.
This item appears in the following Collection(s)
- Academic publications [227425]
- Electronic publications [107155]
- Faculty of Medical Sciences [86157]
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