Empowering malaria vaccination by drug administration.
SourceCurrent Opinion in Immunology, 22, 3, (2010), pp. 367-73
01 juni 2010
Article / Letter to editor
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Current Opinion in Immunology
SubjectN4i 3: Poverty-related infectious diseases; NCMLS 1: Infection and autoimmunity
Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage. The premise is to modulate the immune response with drugs that neutralize suppressive functions and potentiate protective responses. Chloroquine may be a first attractive candidate facilitating protective cellular immune responses by improving cross-presentation and reducing suppressive regulatory T cell responses.
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