Publication year
2010Source
Current Opinion in Immunology, 22, 3, (2010), pp. 367-73ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor
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Organization
Medical Microbiology
Journal title
Current Opinion in Immunology
Volume
vol. 22
Issue
iss. 3
Page start
p. 367
Page end
p. 73
Subject
N4i 3: Poverty-related infectious diseases; NCMLS 1: Infection and autoimmunityAbstract
Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage. The premise is to modulate the immune response with drugs that neutralize suppressive functions and potentiate protective responses. Chloroquine may be a first attractive candidate facilitating protective cellular immune responses by improving cross-presentation and reducing suppressive regulatory T cell responses.
This item appears in the following Collection(s)
- Academic publications [238586]
- Faculty of Medical Sciences [90409]
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