Subject:
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IGMD 6: Hormonal regulation N4i 1: Pathogenesis and modulation of inflammation N4i 4: Auto-immunity, transplantation and immunotherapy NCEBP 2: Evaluation of complex medical interventions NCEBP 5: Health care ethics NCEBP 8: Psychological determinants of chronic illness NCEBP 8: Psychological determinants of chronic illness Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc |
Organization:
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Medical Psychology Laboratory of Genetic, Endocrine and Metabolic Diseases Rheumatology |
Journal title:
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Arthritis Research & Therapy
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Abstract:
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INTRODUCTION: Stressful events are thought to contribute to the aetiology, maintenance and exacerbation of rheumatic diseases. Given the growing interest in acute stress responses and disease, this review investigates the impact of real-life experimental psychosocial, cognitive, exercise and sensory stressors on autonomic, neuroendocrine and immune function in patients with inflammatory rheumatic diseases. METHODS: Databases Medline, PsychINFO, Embase, Cinahl and Pubmed were screened for studies (1985 to 2009) investigating physiological stress responses in inflammatory rheumatic diseases. Eighteen articles met the inclusion criteria. RESULTS: Results suggest that immune function may be altered in response to a stressor; such alterations could contribute to the maintenance or exacerbation of inflammatory rheumatic diseases during stressful events in daily life. CONCLUSIONS: This review emphasizes the need for more experimental research in rheumatic populations with controlled stress paradigms that include a follow-up with multiple evaluation points, simultaneous assessment of different physiological stress systems, and studying factors contributing to specific physiological responses, such as stress appraisal.
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