Experts' opinions on ethical issues of genetic research into Alzheimer's disease: results of a Delphi study in the Netherlands.
until further notice
SourceClinical Genetics, 77, 4, (2010), pp. 382-388
1 april 2010
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
SubjectN4i 3: Poverty-related infectious diseases; NCEBP 11: Alzheimer Centre; NCEBP 1: Molecular epidemiology; NCEBP 2: Evaluation of complex medical interventions; NCEBP 5: Health care ethics; NCEBP 7: Effective primary care and public health; ONCOL 5: Aetiology, screening and detection
Most publications on the ethical aspects of genetic research into Alzheimer's Disease (AD) concentrate on the differences between the opinions of professionals and non-professionals. Differences in rating of morally relevant issues between groups of professionals have not yet been described. A modified Delphi study in two rounds was held to identify differences between groups of experts (i.e. clinicians, representatives of patient organisations, ethicists and persons with a commercial background). The strongest correlation was found between the opinions of ethicists and representatives of patient organisations (0.67) and between clinicians and ethicists (0.62). Moderate correlation (0.55) was found between the opinions of clinicians and representatives of patient organisations. Persons with a commercial background showed a weak correlation with clinicians (0.41), ethicists (0.35) and representatives of patient organisations (0.30). These differences in rating of morally relevant issues between various professional groups are relevant for clinical practice and dementia care, particularly the different rating of prenatal diagnosis found between clinicians and representatives of patient organisations. Interdisciplinary consultations between various professional groups -including at least researchers, clinicians and ethicists -are recommended to guarantee that all considerations will be incorporated into the debate on ethical issues of genetic research into AD.
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