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Publication year
2010Author(s)
Source
Nature Genetics, 42, 6, (2010), pp. 508-14ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor

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Organization
Human Genetics
Radboudumc Extern
Rheumatology
Journal title
Nature Genetics
Volume
vol. 42
Issue
iss. 6
Page start
p. 508
Page end
p. 14
Subject
IGMD 3: Genomic disorders and inherited multi-system disorders; N4i 4: Auto-immunity, transplantation and immunotherapy; NCEBP 1: Molecular epidemiology; NCEBP 2: Evaluation of complex medical interventions; NCEBP 5: Health care ethicsAbstract
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.
This item appears in the following Collection(s)
- Academic publications [202563]
- Electronic publications [100732]
- Faculty of Medical Sciences [79925]
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