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Publication year
2010Source
The Anatomical Record. Part A, Discoveries in Molecular, Cellular and Evolutionary Biology, 293, 6, (2010), pp. 955-967ISSN
Annotation
1 juni 2010
Publication type
Article / Letter to editor

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Organization
Biochemistry (UMC)
Pulmonary Diseases
Journal title
The Anatomical Record. Part A, Discoveries in Molecular, Cellular and Evolutionary Biology
Volume
vol. 293
Issue
iss. 6
Page start
p. 955
Page end
p. 967
Subject
N4i 1: Pathogenesis and modulation of inflammation; NCMLS 3: Tissue engineering and pathologyAbstract
There is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the role it plays in development and disease. There is a rapid change from the classical view of the ECM as a supporting structure towards a view of the ECM as a regulatory entity with profound effects on proliferation, migration, and differentiation of pulmonary cells. In the ECM, a variety of molecules is present in a highly organized pattern. Next to the abundant fiber-forming molecules such as collagens and elastin, a large number of less abundant molecules are part of the ECM, including proteoglycans. In this review, we will focus on one class of proteoglycans, the heparan sulfate proteoglycans. We will particularly address the structure, biosynthesis, and function of their saccharide moiety, the heparan sulfates, including their role in development and (patho)physiology.
This item appears in the following Collection(s)
- Academic publications [204887]
- Electronic publications [103214]
- Faculty of Medical Sciences [81046]
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