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Publication year
2010Author(s)
Source
European Journal of Immunology, 40, 3, (2010), pp. 599-606ISSN
Annotation
01 maart 2010
Publication type
Article / Letter to editor
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Organization
Internal Medicine
Journal title
European Journal of Immunology
Volume
vol. 40
Issue
iss. 3
Page start
p. 599
Page end
p. 606
Subject
N4i 1: Pathogenesis and modulation of inflammationAbstract
Although there has been a great amount of progress in the 25 years since the first reporting of the cDNA for IL-1alpha and IL-1beta, the history of IL-1 goes back to the early 1940s. In fact, the entire field of inflammatory cytokines, TLR and the innate immune response can be found in the story of IL-1. This Viewpoint follows the steps from the identification of the fever-inducing activities of "soluble factors" produced by endotoxin-stimulated leukocytes through to the discovery of cryopyrin and the caspase-1 inflammasome and on to the clinical benefits of anti-IL-1beta-based therapeutics. It also discusses some of the current controversies regarding the activation of the inflammasome. The future of novel anti-inflammatory agents to combat chronic inflammation is based, in part, on the diseases that are uniquely responsive to anti-IL-1beta, which is surely a reason to celebrate the 25th anniversary of the cloning of IL-1alpha and IL-1beta.
This item appears in the following Collection(s)
- Academic publications [245104]
- Electronic publications [132391]
- Faculty of Medical Sciences [93207]
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