In vivo bone response and mechanical evaluation of electrosprayed CaP nanoparticle coatings using the iliac crest of goats as an implantation model.
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Publication year
2010Source
Acta Biomaterialia, 6, 6, (2010), pp. 2227-36ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor
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Organization
Dentistry
Oral and Maxillofacial Surgery
Plastic Surgery
Journal title
Acta Biomaterialia
Volume
vol. 6
Issue
iss. 6
Page start
p. 2227
Page end
p. 36
Subject
NCEBP 2: Evaluation of complex medical interventions; NCMLS 3: Tissue engineering and pathologyAbstract
Recent trends in clinical implantology include the use of endosseous dental implant surfaces embellished with nano-sized modifications. The current study was initiated to evaluate the mechanical properties, as well as the potential beneficial effects, of electrosprayed CaP nanoparticle-coated (nano-CaP) implants on the in vivo osteogenic response, compared with grit-blasted, acid-etched (GAE) implant surfaces as controls. For this purpose nano-CaP coatings were deposited on cylindrical screw-type (St) implants and implanted bilaterally into the iliac crest of goats for 6weeks. In addition to histological and histomorphometrical analyses, insertion torque and removal torque values were measured on implant placement and retrieval, respectively. The present study showed similar insertion and removal torque values for nano-CaP-coated and GAE control implants, with no statistically significant increase in torque value during the implant period for either group. With regard to bone-implant contact and peri-implant bone volume, no significant differences were found between nano-CaP-coated and GAE implants after 6weeks implantation. In conclusion, this study has demonstrated that in situations in which implants are placed in a non-compromised situation using a standard press fit implantation strategy the performance of electrosprayed nano-CaP coatings is comparable with GAE implants, both with respect to implant fixation and bone healing response.
This item appears in the following Collection(s)
- Academic publications [243984]
- Electronic publications [130762]
- Faculty of Medical Sciences [92811]
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