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Publication year
2010Source
Biomaterials, 31, 14, (2010), pp. 3910-9ISSN
Annotation
01 mei 2010
Publication type
Article / Letter to editor

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Organization
Gynaecology
Urology
Paediatrics - OUD tm 2017
Biochemistry (UMC)
Pathology
Journal title
Biomaterials
Volume
vol. 31
Issue
iss. 14
Page start
p. 3910
Page end
p. 9
Subject
NCEBP 14: Cardiovascular diseases; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational researchAbstract
In spina bifida the neural tube fails to close during the embryonic period and it is thought that prolonged exposure of the unprotected spinal cord to the amniotic fluid during pregnancy causes additional neural damage. Intra-uterine repair might protect the neural tissue from exposure to amniotic fluid and might reduce additional neural damage. Biodegradable collagen scaffolds may be useful in case of fetal therapy for spina bifida, but biochemical properties need to be studied. The aim of this study was to investigate whether biodegradable collagen scaffolds can be used to treat full-thickness fetal skin defects. We hypothesized that the pro-angiogenic growth factors VEGF and FGF2 would enhance vascularization, epidermialization and lead to improved wound healing. To investigate the effect of these two growth factors, a fetal sheep model for skin defects was used. Compared to wounds treated with bare collagen scaffolds, wounds treated with growth factor-loaded scaffolds showed excessive formation of capillaries and less myofibroblasts were present in these wounds, leading to less contraction. This study has demonstrated that collagen scaffolds can be used to treat fetal skin defects and that the combination of collagen scaffolds with VEGF and FGF2 had a beneficial effect on wound healing.
This item appears in the following Collection(s)
- Academic publications [227425]
- Electronic publications [107141]
- Faculty of Medical Sciences [86157]
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