Acute stress modulates genotype effects on amygdala processing in humans.
until further notice
SourceProceedings of the National Academy of Sciences USA, 107, 21, (2010), pp. 9867-72
Article / Letter to editor
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Donders Centre for Cognitive Neuroimaging
PI Group Memory & Emotion
F.C. Donders Centre for Cognitive Neuroimaging
Proceedings of the National Academy of Sciences USA
Subject130 000 Cognitive Neurology & Memory; 130 001 Bridging the gap: hippocampus and memory; 130 026 VENI Hermans, ‘In a fit of fear’; 130 027 Brain Imaging Genetics - Alzheimer Disease; DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics; IGMD 3: Genomic disorders and inherited multi-system disorders
Probing gene-environment interactions that affect neural processing is crucial for understanding individual differences in behavior and disease vulnerability. Here, we tested whether the current environmental context, which affects the acute brain state, modulates genotype effects on brain function in humans. We manipulated the context by inducing acute psychological stress, which increases noradrenergic activity, and probed its effect on tonic activity and phasic responses in the amygdala using two MRI techniques: conventional blood oxygen level-dependent functional MRI and arterial spin labeling. We showed that only carriers of a common functional deletion in ADRA2B, the gene coding for the alpha2b-adrenoreceptor, displayed increased phasic amygdala responses under stress. Tonic activity, reflecting the perfusion of the amygdala, increased independently of genotype after stress induction. Thus, when tonic activity was heightened by stress, only deletion carriers showed increased amygdala responses. Our results demonstrate that genetic effects on brain operations can be state dependent, such that they only become apparent under specific, often environmentally controlled, conditions.
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