Fulltext:
87897.pdf
Embargo:
until further notice
Size:
415.2Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2010Source
Biochimica et Biophysica Acta-Reviews on Cancer, 1806, 2, (2010), pp. 193-9ISSN
Annotation
01 december 2010
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Tumorimmunology
Radiation Oncology
Journal title
Biochimica et Biophysica Acta-Reviews on Cancer
Volume
vol. 1806
Issue
iss. 2
Page start
p. 193
Page end
p. 9
Subject
NCMLS 2: Immune Regulation; ONCOL 3: Translational researchAbstract
Nuclear receptors (NR) are intracellular receptors that execute a transcriptional program upon binding to hormones, vitamins and metabolic products. They are key regulators of distinct physiological processes, including growth and differentiation, metabolism, and immunity. The impact of NR activation on a given cell can differ from proliferation induction to programmed cell death. NR malfunction is associated with different diseases, such as diabetes, chronic inflammatory diseases and cancer. Much progress has been made towards understanding the transcriptional regulation by individual NR at the molecular level. However, essentially every cell expresses multiple NR and will encounter complex mixtures of NR ligands during its life cycle. In this review, we will focus on novel insights in balancing NR activity via NR crosstalk and DC-SCRIPT/ZNF366, a bi-functional NR coregulator. The impact on breast cancer development and prognosis will be discussed.
This item appears in the following Collection(s)
- Academic publications [245103]
- Electronic publications [132420]
- Faculty of Medical Sciences [93207]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.