Lack of association of C-C chemokine receptor 5 Delta32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity.
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Publication year
2010Source
The Journal of Rheumatology, 37, 11, (2010), pp. 2226-31ISSN
Annotation
01 november 2010
Publication type
Article / Letter to editor
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Organization
Cell Biology (UMC)
Nephrology
Journal title
The Journal of Rheumatology
Volume
vol. 37
Issue
iss. 11
Page start
p. 2226
Page end
p. 31
Subject
N4i 4: Auto-immunity, transplantation and immunotherapy; IGMD 9: Renal disorderAbstract
OBJECTIVE: C-C chemokine receptor 5 (CCR5) plays an important role in inflammation. A 32 base-pair (Delta32) deletion in the CCR5 gene leads to a nonfunctional receptor. This deletion has been reported to have a protective effect on the development and progression of several autoimmune diseases. We investigated whether the Delta32 deletion is associated with disease susceptibility in a population of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and lupus nephritis (LN); and whether it is associated with disease severity. METHODS: DNA samples from 405 RA patients, 97 SLE patients, 113 LN patients, and 431 healthy controls were genotyped for the CCR5 Delta32 deletion. Differences in genotype frequencies were tested between patients and controls. Association of genotypes with disease severity was analyzed. RESULTS: Genotype frequencies of each group were in Hardy-Weinberg equilibrium. The genotype frequencies of patients did not differ significantly from controls (CCR5/Delta32, Delta32/Delta32: RA 18.3% and 1.2%, respectively; SLE 17.5% and 2.1%; LN 13.3% and 1.8%; controls 20.0% and 2.8%). However, there was a trend for lower Delta32 deletion allele frequency in LN patients compared to controls (p = 0.08). There was no significant association between the CCR5 status and disease severity in RA, SLE, or LN. CONCLUSION: Although an association with LN cannot be excluded, the CCR5 Delta32 deletion does not seem to be a disease susceptibility genotype for RA, SLE, or LN. No significant effect of the Delta32 deletion on disease severity was demonstrated.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
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