until further notice
SourceJournal of Surgical Oncology, 101, 3, (2010), pp. 259-69
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal of Surgical Oncology
SubjectONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection
Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC.
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